The algorithm is described in the ISO 3309 standard.

Manually curated information for which there is published experimental evidence.

Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993))

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In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.

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This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. Manual assertion based on experiment ini,

Manually curated information which has been propagated from a related experimentally characterized protein.

The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.

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Information which has been generated by the UniProtKB automatic annotation system, without manual validation.

Automatic assertion according to rulesi,

Information which has been imported from another database using automatic procedures.

Tested in Human, Mouse. ... Nucleotide carrier signature motif By similarity ... UniProt Consortium European Bioinformatics Institute Protein Information Resource SIB Swiss Institute of Bioinformatics. The version number for both the entry and the canonical sequence are also displayed.

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This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).

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This section contains any relevant information that doesn't fit in any other defined sections

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, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, adenine transmembrane transporter activity, Proc. This is known as the 'taxonomic identifier' or 'taxid'.

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This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. This is known as the 'taxonomic identifier' or 'taxid'.

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This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism.

Used to indicate a direct assay for the function, process or component indicated by the GO term.

solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Synonyms adenine nucleotide translocase-1, Ant1 There are no reviews for Adenine Nucleotide Translocase 1 Antibody (NBP1-59594). Priority is given to the annotation of physiological ligands.

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Manually curated information which has been propagated from a related experimentally characterized protein.

The information is extracted from the scientific literature and diseases that are also described in the OMIM database are represented with a controlled vocabulary in the following way:

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This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.

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When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.

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This indicates the type of evidence that supports the existence of the protein.

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This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.

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, Adenine nucleotide translocator ATP/ADP translocase,

Information which has been imported from another database using automatic procedures.

SLC25A4 Protein name: ANT1 (adenine nucleotide translocase-1) Aliases: AAC1, T1, PEO2, PEO3 Substrates: ADP, ATP Transport type: Exchanger / ADP, ATP Tissue and cellular expression: heart, skeletal muscle, much less in brain, pancreas, prostate, kidney, lung, thymus Subcellular expression: inner mitochondrial membrane Disease: AAC1 deficiency, autosomal dominant … It is useful for tracking sequence updates.

However UniProtKB may contain entries with identical sequences in case Validated in WB, ICC/IF. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges free ATP with free ADP across the inner mitochondrial membrane. Independently reviewed in 1 review(s). DNA Data Bank of Japan; a nucleotide sequence database, Ensembl protists genome annotation project, Database of genes from NCBI RefSeq genomes, KEGG: Kyoto Encyclopedia of Genes and Genomes, Database of comparative protein structure models, ProtoNet; Automatic hierarchical classification of proteins, MobiDB: a database of protein disorder and mobility annotations. Protein sets from fully sequenced genomes.

It should be noted that while, in theory, two different sequences could The gene encoding adenine nucleotide translocator-3 is located in the pseudoautosomal region (PAR) at the end of the short arm of the X and Y chromosomes. ADP/ATP translocase 2 is a protein that in humans is encoded by the SLC25A5 gene on the X chromosome. Please consider upgrading,

An evidence describes the source of an annotation, e.g. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.

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This section provides any useful information about the protein, mostly biological knowledge.

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The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:

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UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.

Examples: P92958, Q8TDN4, O14734

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. Solute carrier family 25 member 5 It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.

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This subsection of the Names and taxonomy section is present for entries that are part of a proteome, i.e. Adenine Nucleotide Translocator at popflock.com May localize to non-mitochondrial membranes (PubMed:

Inferred from Direct Assay

Organism. U.S.A. 84:7580-7584(1987), generation of precursor metabolites and energy, mitochondrial ADP transmembrane transport, mitochondrial ATP transmembrane transport, negative regulation of necroptotic process, integral component of mitochondrial membrane, Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 2 (PEOA2), Mitochondrial DNA depletion syndrome 12B, cardiomyopathic type (MTDPS12B), Mitochondrial DNA depletion syndrome 12A, cardiomyopathic type (MTDPS12A), Solute carrier family 25 member 4 isoform 1 (Fragment), Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 4, Human polymorphisms and disease mutations, Human entries with polymorphisms or disease mutations. Expressed in erythrocytes (at protein level). 3 Sequences. Systems used to automatically annotate proteins with high accuracy: Select one of the options below to target your search: Select item(s) and click on "Add to basket" to create your own collection here (400 entries max),

Manually curated information for which there is published experimental evidence.

SWISS-MODEL Repository - a database of annotated 3D protein structure models, Database of comparative protein structure models, evolutionary genealogy of genes: Non-supervised Orthologous Groups, Identification of Orthologs from Complete Genome Data, Database for complete collections of gene phylogenies, Gene3D Structural and Functional Annotation of Protein Families, Integrated resource of protein families, domains and functional sites, Protein Motif fingerprint database; a protein domain database, Superfamily database of structural and functional annotation, PROSITE; a protein domain and family database. Add Adenine Nucleotide Translocator to your PopFlock.com topic list or share. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.

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This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen; Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen riers include electroneutral uniport, electroneutral exchange, electrophoretic exchange, and electrophoretic uniport. Involved in mitochondrial ADP/ATP transport. The disease is caused by mutations affecting the gene represented in this entry.

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ADP,ATP carrier protein 2. The algorithm is described in the ISO 3309 standard. (Microbial infection) Interacts with HIV-1 Vpr. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.

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, Automatic assertion inferred from database entries,

This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein. Rabbit Polyclonal Adenine Nucleotide Translocase 1 antibody. Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase. The ANTKMT gene encodes a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase (ANT) and affects mitochondrial respiration (Malecki et al., 2019). We'd like to inform you that we have updated our Privacy Notice to comply

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When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.

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This indicates the type of evidence that supports the existence of the protein. Willemen et al.

Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.

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This section provides information on the disease(s) and phenotype(s) associated with a protein.

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This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. of multiple genes (paralogs).

Get Adenine Nucleotide Translocator essential facts. Adenine nucleotide translocase (ANT) is the unique catalyst of ADP/ATP exchanges across the mitochondrial inner membrane. with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. Systems used to automatically annotate proteins with high accuracy: Select one of the options below to target your search: Select item(s) and click on "Add to basket" to create your own collection here (400 entries max),

Information which has been generated by the UniProtKB automatic annotation system, without manual validation.

ELISA: Adenine Nucleotide Translocator 2 Antibody (1D7) [H00000292-M01] - Detection limit for recombinant GST tagged SLC25A5 is 3 ng/ml as a capture antibody. In contrast to the K+/H+ antiporter, K+ uniport shows little dependence on pH. have the same checksum value, the likelihood that this would happen

Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
ANT is the most abundant protein in the inner mitochondrial membrane and belongs to mitochondrial carrier family. This protein functions as an antiporter for ADP/ATP exchange between the mitochondrial matrix and cytoplasm. The Biological General Repository for Interaction Datasets (BioGRID), Protein interaction database and analysis system, STRING: functional protein association networks. Protein Ontology. using the generator polynomial: x64 + x4 + x3 + x + 1. Sequence conflicts are usually of unknown origin.

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This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (UniRef).

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This section is used to point to information related to entries and found in data collections other than UniProtKB.

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This section provides general information on the entry.

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This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. The maximum percent inhibition is increased from 40 to 60% by treatment of mitochondria with N-ethylmaleimide (30 nmol/mg) which stimulates K+ uniport 3.6-fold.